Vision Problems Emerge as Astronauts Spend Months in Orbit
by Melissa L. Gaskill, NASA
When astronauts began spending six months and more aboard the International Space Station (ISS), they experienced a range of vision changes. Many astronauts reported the need for stronger reading glasses as their missions progressed. Research into this phenomenon revealed swelling in the optic disk, the point where the optic nerve enters the retina, along with alterations in the shape of the eye. These combined symptoms were classified as Space-Associated Neuro-Ocular Syndrome (SANS).
This article explores the implications of SANS, the contributing factors, and ongoing research aimed at understanding and potentially mitigating these vision issues.

Microgravity plays a significant role in these changes, as it causes a redistribution of fluids within the body. This altered fluid distribution can lead to an increased fluid balance in the head, contributing to the swelling in the optic disk and other changes associated with SANS.
Research into the Causes of Vision Changes
Ongoing studies aim to better understand why astronauts develop SANS during long-term space missions. The following investigations frame current research approaches:
- Fluid Shifts Investigation (2015-2020): The first study to highlight changes in how blood drains from the brain in microgravity, providing key insights into SANS development.
- Thigh Cuff Investigation: This study examines whether the use of tight leg cuffs can moderate fluid movements within the body, potentially mitigating headward fluid shifts and related issues.
- Vision Impairment and Intracranial Pressure (VIIP): A project assessing how fluid shifts and increased intracranial pressure may influence SANS. Data collection includes clinical eye exams and neuroimaging techniques.
These investigations have employed advanced imaging techniques. For instance, successful utilization of techniques like Optical Coherence Tomography (OCT) has improved diagnostics so that researchers can visualize changes in the eye tissues more effectively. For example:

Studies have also focused on measuring the diameter of the optic nerve sheath as a potential biomarker for diagnosing SANS. Additional research is examining the optic nerve's stiffness, as changes in tissue characteristics may influence SANS severity.
Recent Findings and Their Implications
Recent publications have provided significant insights into SANS and its potential management:
| Study | Findings |
|---|---|
| Imaging Techniques Advancements | Description: Enhancements in imaging techniques provide clearer insights into SANS, improving diagnosis and understanding. |
| Optic Nerve Sheath Measurement | Outcome: The optic nerve sheath diameter is promising for evaluating eye changes during spaceflight that can aid in diagnosing SANS. |
| Individual Astronaut Case Study | Improvements in symptoms post mission may relate to changes in environmental conditions; individual insights provide clues for broader implications. |
The findings indicate that environmental management, including dietary impacts from B vitamins and cognitive factors like cabin CO2 levels, may play a role in SANS severity.
Looking Forward: Potential Countermeasures
Research efforts target methods aimed at preventing, diagnosing, and treating SANS. Among these approaches are:
- The implementation of artificial gravity to help mitigate fluid shifts could offer promising results in preserving astronaut health during long missions.
- Utilizing dietary adjustments, particularly through vitamin supplementation, shows potential for addressing SANS symptoms.
- Developing non-invasive tools for real-time assessment is crucial for monitoring ocular health.
These insights not only influence astronauts' healthcare strategies but also extend implications for terrestrial treatments of similar vision-related conditions.
Provided by NASA